Department ofBiochemistry & Cellular Biology

Hoshino's current and former lab members are underlined. His current affiliation is underlined in bold.

2025

• Gaynor L, Singh H, Tie G, Badarinath K, Madha S, Mancini A, Bhattacharya S, Hoshino M, de Sauvage FJ, Murata K, Jadhav U, Shivdasani RA. Crypt density and recruited enhancers underlie intestinal tumour initiation. Nature. 2025 Jan 8. doi: 10.1038/s41586-024-08573-9. Epub ahead of print. PMID: 39778708.https://www.nature.com/articles/s41586-024-08573-9

2024

• Shiraishi R Cancila G, Kumegawa K, Torrejon J, Basili I, Bernardi F, Silva PBGD, Wang W, Chapman O, Yang L, Jami M, Nishitani K, Arai Y, Xiao Z, Yu H, Lo Re V, Marsaud V, Talbot J, Lombard B, Loew D, Jingu M, Okonechnikov K, Sone M, Motohashi N, Aoki Y, Pfister SM, Chavez L, Hoshino M, Maruyama R, Ayrault O, Kawauchi D. Cancer-specific epigenome identifies oncogenic hijacking by nuclear factor I family proteins for medulloblastoma progression. Developmental Cell. doi: 10.1016/j.devcel.2024.05.013
• Enokida T, Yoshida N, Tatsumi M, Hidese S, Goto Y, Hoshino M, KunugiH, Hattori K. Neuronal autoantibodies in the cerebrospinal fluid of 148 patients with schizophrenia and 151 healthy controls. Heliyon. doi: 10.1016/j.heliyon.2024.e30695.
• Dewa K, Arimura N, Kakegawa W, Itoh M, Adachi T, Miyashita S, Inoue YU, Hizawa K, Hori K, Honjoya N, Yagishita H, Taya S, Miyazaki T, Usui C, Tatsumoto S, Tsuzuki A, Uetake H, Sakai K, Yamakawa K, Sasaki T, Nagai J, Kawaguchi Y, Sone M, Inoue T, Go Y, Ichinohe N, Kaibuchi K, Watanabe M, Koizumi S, Yuzaki M, Hoshino M. Neuronal DSCAM regulates the peri-synaptic localization of GLAST in Bergmann glia for functional synapse formation. Nature Communications. doi: 10.1038/s41467-023-44579-z
• Iijima K, Komatsu K, Miyashita S, Suyama K, Murayama K, Hashizume K, Tabe NK, Miyata H, Iwasaki M, Taya S, Hoshino M. Transcriptional features of low-grade neuroepithelial tumors with the BRAF V600E mutation associated with epileptogenicity. Genes Cells. 2024 Mar;29(3):192-206. doi: 10.1111/gtc.13096. Epub 2024 Jan 25. PMID: 38269481.
• Enokida T, Hattori K, Okabe K, Noda T, Ota M, Sato N, Ogawa S, Tatsumi M, Hoshino M, Kunugi H, Nakagome K. Possible association of elevated CSF IL-6 levels with anxiety and frustration in psychiatric disorders. Psychiatry Clin Neurosci. 2024 Sep 24. doi: 10.1111/pcn.13743. Epub ahead of print. PMID: 39317977.
• Enokida T, Hattori K, Ota M, Tatsumi M, Hidese S, Sato N, Hoshino M, Kunugi H. Correlation between myelin basic protein levels in cerebrospinal fluid and motor speed in patients with schizophrenia. Neuropsychopharmacol Rep. 2024 Sep;44(3):663-670. doi: 10.1002/npr2.12471. Epub 2024 Aug 12. PMID: 39133634; PMCID: PMC11544460.
• Sharmin Naher, Kenji Iemura, Satoshi Miyashita, Mikio Hoshino, Kozo Tanaka, Shinsuke Niwa, Jin-Wu Tsai, Takako Kikkawa, Noriko Osumi. Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex. EMBO J. (2024) https://doi.org/10.1038/s44318-024-00327-7
• Naher S, Iemura K, Miyashita S, Hoshino M, Tanaka K, Niwa S, Tsai JW, Kikkawa T, Osumi N. Kinesin-like motor protein KIF23 maintains neural stem and progenitor cell pools in the developing cortex. EMBO J. 2025 Jan;44(2):331-355. doi: 10.1038/s44318-024-00327-7. Epub 2024 Dec 4. PMID: 39632980; PMCID: PMC11729872.https://www.embopress.org/doi/full/10.1038/s44318-024-00327-7

2023

• Hagihara H, Shoji H, Hattori S, Sala G, Takamiya Y, Tanaka M, Ihara M, Shibutani M, Hatada I, Hori K, Hoshino M, Nakao A, Mori Y, Okabe S, Matsushita M, Urbach A, Katayama Y, Matsumoto A, Nakayama K., Katori S, Sato T, Iwasato T, Nakamura H, Goshima Y, Raveau M, Tatsukawa T, Yamakawa K, Takahashi N, Kasai H, Inazawa J, Nobuhisa I, Kagawa T, Taga T, Darwish M, Nishizono H, Takao K, Sapkota K, Nakazawa K, Takagi T, Fujisawa H, Sugimura Y, Yamanishi K, Rajagopal L, Hannah N D, Meltzer H Y., Yamamoto T, Wakatsuki S, Araki T, Tabuchi K, Numakawa T, Kunugi H, Huang F L., Hayata-Takano A, Hashimoto H, Tamada K, Takumi T, Kasahara T, Kato T, Graef I A., Crabtree G R., Asaoka N, Hatakama H, Kaneko S, Kohno T, Hattori M, Hoshiba Y, Miyake R, Obi-Nagata K, Hayashi-Takagi A, Becker L J., Yalcin I, Hagino Y, Kotajima-Murakami H, Moriya Y, Ikeda K, Kim H, Kaang Bong-Kiun, Otabi H, Yoshida Y, Toyoda A, Komiyama N H., Grant S G. N., Ida-Eto M, Narita M, Matsumoto K, Okuda-Ashitaka E, Ohmori I, Shimada T, Yamagata K, Ageta H, Tsuchida K, Inokuchi K, Sassa T, Kihara A, Fukasawa M, Usuda N, Katano T, Tanaka T, Yoshihara Y, Igarashi M, Hayashi T, Ishikawa K, Yamamoto S, Nishimura N, Nakada K, Hirotsune S, Egawa K, Higashisaka K, Tsutsumi Y, Nishihara S, Sugo N, Yagi T, Ueno N, Yamamoto T, Kubo Y, Ohashi R, Shiina N, Shimizu K, Higo-Yamamoto S, Oishi K, Mori H, Furuse T, Tamura M, Shirakawa H, Sato D X., Inoue Y U., Inoue T, Komine Y, Yamamori T, Sakimura K, Miyakawa T. (2023) Large-scale animal model study uncovers altered brain pH and lactate levels as a transdiagnostic endophenotype of neuropsychiatric disorders involving cognitive impairment. eLife. doi: 10.7554/eLife.89376.2
• Dang Minh Tran, Nozomu Yoshioka, Norihisa Bizen, Yukiko Mori-Ochiai, Masato Yano, Shogo Yanai, Junya Hasegawa, Satoshi Miyashita, Mikio Hoshino, Junko Sasaki, Takehiko Sasaki, Hirohide Takebayashi; Attenuated cerebellar phenotypes in Inpp4a truncation mutants with preserved phosphatase activity. Dis Model Mech 1 July 2023; 16 (7): dmm050169. doi: 10.1242/dmm.050169

2022

• Wang W, Shiraishi R, Kawauchi D*. Shh signalling in cerebellar development and cancer. Front Cell Dev Biol. 10:864035. doi: 10.3389/fcell.2022.864035.
• Ishigaki OA, Takao K, Yamada D, Sekiguchi M, Itoh M, Koshidata Y, Abe M, Natsume R, Kaneko M, Adachi T, Kaizuka T, Suzuki N, Sakimura K, Okuno H, Wada K, Mishina M, Miyakawa T, Hayashi T. Prolonged contextual fear memory in AMPA receptor palmitoylation-deficient mice. Neuropsychopharmacology. 2022 May; 47(12): doi:10.1038/s41386-022-01347-9.
• Izumi R, Hino M, Nagaoka A, Shishido R, Kakita A, Hoshino M, Kunii Y, Yabe H. Unique Lewy pathology in myotonic dystrophy type 1. Neuropathology 2022 Apr; 42(2): 104-116. doi:10.1111/neup.12790.
• Miyashita S, Hoshimo M. Transit amplifying progenitors in the cerebellum: Similarities to and differences from transit amplifying cells in other brain regions and between species. Cells. 2022 Feb 18;11(4): 726. doi: 10.3390/cells11040726.
• Inoue YU, Miwa H, Hori K, Kaneko R, Morimoto Y, Koike E, Asami J, Kamijo S, Yamada M, Hoshino M, Inoue T. Targeting neurons with functional oxytocin receptors: A novel set of simple knock-in mouse lines for oxytocin receptor visualization and manipulation. eNeuro. 2022 Feb 15;9(1) ENEURO.0423-21-2022. doi: 10.1523/ENRUO.0423-21.2022.

2021

• Hori K, Shimaoka K, Hoshino M. AUTS2 gene: Key to understanding the pathogenesis of neurodevelopmental disorders. Cells. 2021 Dec 21; 11(1): 11. doi: 10.3390/cells11010011.
• Inoue YU, Morimoto Y, Yamada M, Kaneko R, Shimaoka K, Oki S, Hotta M, Asami J, Koike E, Hori K, Hoshino M, Imayoshi I, Inoue T. An optimized preparation method for long ssDNA donors to facilitate quick knock-in mouse generation. Cells. 2021 Apr 30; 10(5): 1076. doi: 10.3390/cells10051076.
• Miyashita S, Owa T, Seto Y, Yamashita M, Aida S, Sone M, Ichijo K, Nishioka T, Kaibuchi K, Kawaguchi Y, Taya S, Hoshino M. Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1. EMBOJ 2021 Jul 15; 40(14): e105712. doi: 10.15252/emboj.2020105712.
• Shiraishi R, Kawauchi D. Epigenetic regulation in medulloblastoma pathogenesis revealed by genetically engineered mouse models. Cancer Sci. 2021 Aug;112(8):2948-2957. doi: 10.1111/cas.14990.
• Ogata S, Hashizume K, Hayase Y, Kanno Y, Hori K, Balan S, Yoshikawa T, Takahashi H, Taya S, Hoshino M. Potential involvement of DSCAML1 mutations in neurodevelopmental disorders. Genes Cells. 2021 Jan 27. doi: 10.1111/gtc.12831.
• Zheng T, Ghasemi DR, Okonechnikov K, Korshunov A, Sill M, Maass KK,Benites Goncalves da Silva P, Ryzhova M, Gojo J, Stichel D, Arabzade A, Kupp R, Benzel J, Taya S, Adachi T, Shiraishi R, Gerber NU, Sturm D, Ecker J, Sievers P, Selt F, Chapman R, Haberler C, Figarella-Branger D, Reifenberger G, Fleischhack G, Rutkowski S, Donson AM, Ramaswamy V, Capper D, Ellison DW, Herold-Mende CC, Schüller U, Brandner S, Driever PH, Kros JM, Snuderl M, Milde T, Grundy RG, Hoshino M, Mack SC, Gilbertson RJ, Jones DTW, Kool M, Deimling AV, Pfister SM, Sahm F*, Kawauchi D*, Pajtler KW*. Cross-species genomics reveals oncogenic dependencies in ZFTA/C11orf95 fusion-positive supratentorial ependymomas. Cancer Discov. 2021:11(9):2230-2247. *Co-corresponding author.
• Adachi T, Miyashita S, Yamashita M, Shimoda M, Okonechnikov K, Chavez L, Kool M, Pfister SM, Inoue T, Kawauchi D, Hoshino M*. Notch Signaling between Cerebellar Granule Cell Progenitors. eNeuro. 2021:ENEURO.0468-20.
• Haag D, Mack N, Benites Goncalves da Silva P, Statz B, Clark J, Tanabe K, Sharma T, Jäger N, Jones DTW, Kawauchi D, Wernig M*, Pfister SM*. H3.3-K27M drives neural stem cell-specific gliomagenesis in a human iPSC-derived model. Cancer Cell. 2021:39(3):407-422.

2020

• Hayase Y, Amano S, Hashizume K, Tominaga T, Miyamoto H, Kanno Y, Ueno-Inoue Y, Inoue T, Yamada M, Ogata S, Balan S, Hayashi K, Miura Y, Tokudome K, Ohno Y, Nishijo T, Momiyama T, Yanagawa Y, Takizawa A, Mashimo T, Serikawa T, Sekine A, Nakagawa E, Takeshita E, Yoshikawa T, Waga C, Inoue K, Goto YI, Nabeshima Y, Ihara N, Yamakawa K, Taya S, Hoshino M.
  Down syndrome cell adhesion molecule like-1 (DSCAML1) links the GABA system and seizure susceptibility.
  Acta Neuropathol Commun. 2020 Nov 30;8(1):206. doi: 10.1186/s40478-020-01082-6.
• Hiraga K, Inoue YU, Asami J, Hotta M, Morimoto Y, Tatsumoto S, Hoshino M, Go Y, Inoue T.
  Redundant type II cadherins define neuroepithelial cell states for cytoarchitectonic robustness.
  Commun Biol. 2020 Oct 15;3(1):574. doi: 10.1038/s42003-020-01297-2
• Yamashiro K, Hori K, Esther L, Aoki R, Shimaoka K, Arimura N, Egusa SF, Sakamoto A, Abe M, Sakimura K, Watanabe T, Uesaka N, Kano M, Hoshino M.
  AUTS2 governs cerebellar development purkinje cell maturation, motor function and social communication
  iScience. 2020 Dec 18. doi : 10.1016/j.isci.2020.101820
• Yamashita M, Owa T, Shiraishi R, Adachi T, Ichijo K, Taya S, Miyashita S, Hoshino M.
  The role of SCFSkp2 and SCFβ-TrCP1/2 in the cerebellar granule cell precursors.
  Genes Cells. 2020 Oct 6. doi: 10.1111/gtc.12813. Online ahead of print.
• Kutscher LM, Okonechnikov K, Batora NV, Clark J, Silva PBG, Vouri M, van Rijn S, Sieber L, Statz B, Gearhart MD, Shiraishi R, Mack N, Orr BA, Korshunov A, Gudenas BL, Smith KS, Mercier AL, Ayrault O, Hoshino M, Kool M, von Hoff K, Graf N, Fleischhack G, Bardwell VJ, Pfister SM, Northcott PA, Kawauchi D*.
  Functional loss of a noncanonical BCOR-PRC1.1 complex accelerates SHH-driven medulloblastoma formation.
  Genes Dev. 2020 Sep 1;34(17-18):1161-1176. doi: 10.1101/gad.337584.120. Epub 2020 Aug 20.
• Arimura N, Okada M, Taya S, Dewa KI, Tsuzuki A, Uetake H, Miyashita S, Hashizume K, Shimaoka K, Egusa S, Nishioka T, Yanagawa Y, Yamakawa K, Inoue YU, Inoue T, Kaibuchi K, Hoshino M.
  DSCAM regulates delamination of neurons in the developing midbrain
  Science Advances Pub Date:2020 Sep 2;6(36):eaba1693. doi: 10.1126/sciadv.aba1693.PMID: 32917586 DOI: 10.1126/sciadv.aba1693
• Hori K, Yamashiro K, Nagai T, Shan W, Egusa SF, Shimaoka K, Kuniishi H, Sekiguchi M, Go Y, Tatsumoto S, Yamada M, Shiraishi R, Kanno K, Miyashita S, Sakamoto A, Abe M, Sakimura K, Sone M, Sohya K, Kunugi H, Wada K, Yamada M, Yamada K, Hoshino M.
  AUTS2 Regulation of Synapses for Proper Synaptic Inputs and Social Communication.
  iScience. 2020 Jun 26;23(6):101183. doi: 10.1016/j.isci.2020.101183. Epub 2020 May 18.PMID: 32498016 Free PMC article.

2019

• Pajtler KW, Wei Y, Okonechnikov K, Silva PBG, Vouri M, Zhang L, Brabetz S, Sieber L, Gulley M, Mauermann M, Wedig T, Mack N, Imamura Kawasawa Y, Sharma T, Zuckermann M, Andreiuolo F, Holland E, Maass K, Körkel-Qu H, Liu HK, Sahm F, Capper D, Bunt J, Richards LJ, Jones DTW, Korshunov A, Chavez L, Lichter P, Hoshino M, Pfister SM, Kool M, Li W, Kawauchi D.
  YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis.
  Nat Commun. 2019 Sep 2;10(1):3914. doi: 10.1038/s41467-019-11884-5.PMID: 31477715 Free PMC article.
• Shiraishi RD, Miyashita S, Yamashita M, Adachi T, Shimoda MM, Owa T, Hoshino M.
  Expression of transcription factors and signaling molecules in the cerebellar granule cell development.
  Gene Expr Patterns. 2019 Dec;34:119068. doi: 10.1016/j.gep.2019.119068. Epub 2019 Aug 20.PMID: 31437514
• Takizawa H, Hara Y, Mizobe Y, Ohno T, Suzuki S, Inoue K, Takeshita E, Shimizu-Motohashi Y, Ishiyama A, Hoshino M, Komaki H, Takeda S, Aoki Y.
  Modelling Duchenne muscular dystrophy in MYOD1-converted urine-derived cells treated with 3-deazaneplanocin A hydrochloride.
  Sci Rep. 2019 Mar 7;9(1):3807. doi: 10.1038/s41598-019-40421-z.PMID: 30846748 Free PMC article.
• Arimura N, Dewa KI, Okada M, Yanagawa Y, Taya SI, Hoshino M.
  Comprehensive and cell-type-based characterization of the dorsal midbrain during development.
  Genes Cells. 2019 Jan;24(1):41-59. doi: 10.1111/gtc.12656. Epub 2018 Dec 5.

2018

• Ambrozkiewicz MC, Schwark M, Kishimoto-Suga M, Borisova E, Hori K, Salazar-Lazaro A, Rusanova A, Altas B, Piepkorn L, Bessa P, Schaub T, Zhang X, Rabe T, Ripamonti S, Rosario M, Akiyama H, Jahn O, Kobayashi T, Hoshino M, Tarabykin V, Kawabe H.
  Polarity Acquisition in Cortical Neurons Is Driven by Synergistic Action of Sox9-Regulated Wwp1 and Wwp2 E3 Ubiquitin Ligases and Intronic miR-140.
  Neuron100:1097-1115 e1015. doi.org/10.1016/j.neuron.2018.10.008
• Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Marutani M, Shibuya A, Nabeshima Y, Yanagisawa M, Funato H and Hoshino M.
  Forebrain Ptf1a is required for sexual differentiation of the brain.
  Cell Rep., 2018 July 3; 24(1):79-94. doi:10.1016/j.celrep.2018.06.010
• Inoue YU, Morimoto Y, Hoshino M, Inoue T:
  Generation of Pax6-IRES-EGFP knock-in mouse via the cloning-free CRISPR/Cas9 system to reliably visualize neurodevelopmental dynamics.
  Neurosci Res, 2018 Jan 31. pii: S0168-0102(17)30718-6. doi: 10.1016/j.neures.2018.01.007. [Epub ahead of print]
• Owa T, Taya S, Miyashita S, Yamashita M, Adachi T, Yamada K, Yokoyama M, Aida S, Nishioka T, Inoue YU, Goitsuka R, Nakamura T, Inoue T, Kaibuchi K, Hoshino M:
  Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation.
  J Neurosci, 2018 Jan 31;38(5):1277-1294. doi: 10.1523/JNEUROSCI.1545-17.2017. Epub 2018 Jan 9.

2017

• Russo D, Della Ragione F, Rizzo R, Sugiyama E, Scalabrì F, Hori K, Capasso S, Sticco L, Fioriniello S, De Gregorio R, Granata I, Guarracino MR, Maglione V, Johannes L, Bellenchi GC, Hoshino M, Setou M, D’Esposito M, Luini A, D’Angelo G:
  Glycosphingolipid metabolic reprogramming drives neural differentiation.
  EMBO J, 2017 Dec 27. pii: e97674. doi: 10.15252/embj.201797674. [Epub ahead of print]
• Miyashita S*, Adachi T*, Yamashita M, Sota T, Hoshino M:
  Dynamics of the cell division orientation of granule cell precursors during cerebellar development.
  Mech Dev, 2017 Oct;147:1-7. doi: 10.1016/j.mod.2017.06.002. Epub 2017 Jun 17. *These authors contributed equally.
• Hori K, Hoshino M:
  Neuronal Migration and AUTS2 Syndrome.
  Brain Sci, 2017 May 14;7(5). pii: E54. doi: 10.3390/brainsci7050054. Review.
• Hanai S, Sukigara S, Dai H, Owa T, Horike SI, Otsuki T, Saito T, Nakagawa E, Ikegaya N, Kaido T, Sato N, Takahashi A, Sugai K, Saito Y, Sasaki M, Hoshino M, Goto YI, Koizumi S, Itoh M:
  Pathologic Active mTOR Mutation in Brain Malformation with Intractable Epilepsy Leads to Cell-Autonomous Migration Delay.
  Am J Pathol, 2017 May;187(5):1177-1185. doi: 10.1016/j.ajpath.2017.01.015.

2016

• Adachi T, Hayashi T: Evolutionarily conserved phosphorylation and palmitoylation-dependent regulation of dopamine D1-like receptors in vertebrates. Neurotransmitter. 10.14800/nt.1434.
• Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, Sakai K, Hayase Y, Seto Y, Inoue YU, Inoue T, Ichinohe N, Kawaguchi Y, Akiyama H, Koizumi S, Hoshino M:
  Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9.
  Mech Dev, May;140:25-40. doi: 10.1016/j.mod.2016.02.004. Epub 2016 Mar 3.
• Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawke:
  Consensus paper: cerebellar development.
  Cerebellum, 2016 Dec;15(6):789-828. Review.
• Egusa SF, Inoue YU, Asami J, Terakawa YW, Hoshino M, Inoue T:
  Classiic cadherin expressions balance postnatal neuronal positioning and dendrite dynamics to elaborate the specific cytoarchitecture of the mouse cortical area.
  Neurosci Res, 2016 Apr;105:49-64. doi: 10.1016/j.neures.2015.09.006. Epub 2015 Oct 9.

2015

• Hori K, Nagai T, Shan W, Sakamoto A, Abe M, Yamazaki M, Sakimura K, Yamada K, Hoshino M:
  Heterozygous disruption of Autism susceptibility candidate 2 causes impaired emotional control and cognitive memory.
  PLoS One, 10, e0145979, 2015
• Yamaguchi M, Watanabe Y, Ohtani T, Uezumi A, Mikami N, Nakamura M, Sato T, Ikawa M, Hoshino M, Tsuchida K, Miyagoe-Suzuki Y, Tsujikawa K, Takeda S, Yamamoto H, Fukuda S:
  Calcitonin receptor signalling inhibits muscle stem cells from escaping the quiescent state and the niche.
  Cell Reports, 13, 302-314 2015
• Watanabe T, Kakeno M, Matsui T, Sugiyama I, Arimura N, Matsuzawa K, Shirahige A, Ishidate F, Nishioka T, Taya S, Hoshino M, Kaibuchi K:
  TTBK2 with EB1/3 regulates microtubule dynamics in migrating cells through KIF2A phosphorylation.
  J Cell Biol. 2015
• Wright MC, Reed-Geaghan EG, Bolock AM, Fujiyama T, Hoshino M, Maricich SM:
  Unipotent Atoh1+ progenitors maintain the Merkel cell population in embryonic and adult mice.
  J Cell Biol, 208, 367-377, 2015
• Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Musante L, Fischer U, Frints SGM, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H:
  In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.
  Molecular Psychiatry, 20, 459-471, 2015.
• Ruffault P-L, D’Autreaux F, Hayes JA, Nomaksteinsky M, Autran S, Fujiyama T, Hoshino M, Hagglund M, Kiehn O, Brunet J-F, Fortin G, Goridis C:
  The retrotrapezoid nucleus neurons expressing Atoh1 and Phox2b are essential for the respiratory response to CO2.
  eLife, 10.7554, 2015
• De Luca A, Parmigiani E, Tosatto G, Martire S, Hoshino M, Buffo A, Leto K, Rossi F:
  Exogenous Sonic Hedgehog modulates the pool of GABAergic interneurons during cerebellar development.
  Cerebellum, 14, 72-85, 2015.

2014

• Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell KJ, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M:
  Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum.
  Nature Communications, 5, 3337, 2014
• Hori K, Nagai T, Shan W, Sakamoto A, Taya S, Hashimoto R, Hayashi T, Abe M, Yamazaki M, Nakao K, Nishioka T, Sakimura K, Yamada K, Kaibuchi K, Hoshino M:
  Cytoskeletal regulation of AUTS2 in neuronal migration and neuritogenesis.
  Cell Reports, 9, 2166-2179, 2014
• Yamada M, Seto Y, Taya S, Owa T, Inoue YU, Inoue T, Kawaguchi Y, Nabeshima Y, Hoshino M:
  Specification of spatial identities of cerebellar neuronal progenitors by Ptf1a and Atoh1 for proper production of GABAergic and glutamatergic neurons.
  J. Neurosci, 34, 4786-4800, 2014
• Worzfeld T, Swiercz JM, Senturk A, Genz B, Korostylev A, Deng S, Xia J, Hoshino M, Epstein JA, Chang AM, Vollmar B, Acker-Palmer A, Kuner R, Offermanns S:
  Genetic dissection of plexin signalling in vivo.
  Proc Natl Acad Sci USA , 111, 2194-2199, 2014
• Seto Y, Ishiwata S, Hoshino M:
  Characterization of Olig2 expression during cerebellar development.
  Gene Expression Patterns, 15, 1-7, 2014
• Nishimura YV, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, Nagata K, Nakajima K, Kawauchi T:
  Cdk5 and its substrates, DCX and p27-kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons.
  Development, 141, 3540-3550, 2014.

2013

• Chonko KT, Jahan I, Stone J, Wright MC, Fujiyama T, Hoshino M, Fritzsch B, Maricich SM:
  Atoh1 directs hair cell differentiation and survival in the late embryonic mouse inner ear.
  Dev Biol. 381, 401-410, 2013
• Terakawa YW, Inoue YU, Asami J, Hoshino M, Inoue T:
  A sharp Cadherin-6 gene expression boundary in the developing mouse cortical plate demarcates the future functional areal border.
  Cerebral Cortex. 23, 2293-2308, 2013
• Esposito G, Yoshida S, Ohnishi R, Tsuneoka Y, Rostagno Mdel C, Yokota S, Okabe S, Kamiya K, Hoshino M, Shimizu M, Venuti P, Kikusui T, Kato T, Kuroda KO:
  Infant calming responses during maternal carrying in humans and mice.
  Current Biology, 23, 739-745, 2013

2012

• Bjerknes M, Khandanpour C, Moroy T, Fujiyama T, Hoshino M, Klisch TJ, Ding Q, Gan L, Wang J, Martin MG, Chen H:
  Origin of the brush cell lineage in the mouse intestinal epithelium.
  Dev Biol, 362, 194-218, 2012

2011

• Morinaka A, Yamada M, Itofusa R, Funato Y, Yoshimura Y, Nakamura F, Yoshimura T, Kaibuchi K, Goshima Y, Hoshino M, Kamiguchi H, Miki H:
  Thioredoxin mediates oxidation-dependent phosphorylation of CRMP2 and growth cone collapse.
  Sicence Signaling, 4 (170), ra26, 2011
• Goto A, Hoshino M, Matsuda M, Nakamura T:
  Phosphorylation of STEF/Tiam2 by protein kinase A is critical for Rac1 activation and neurite outgrowth in dibutyryl cAMP-treated PC12D cells.
  Mol BIol Cell, 22, 1780-1790, 2011
• Komine O, Nagaoka M, HIraoka Y, Hoshino M, Kawaguchi Y, Pear WS, Tanaka K:
  RBP-J promotes the maturation of neuronal progenitors.
  Dev Biol, 354, 44-54, 2011
• Matsumoto A, Susaki E, Onoyama I, Nakayama K, Hoshino M, Nakayama KI:
  Deregulation of the p57-E2F1-p53 axis results in nonobstructive hydrocephalus and cerebellar malformation in mice.
  Mol Cell Biol, 31, 4176-4192, 2011

2010

• Kawauchi T, Sekine K, Shikanai M, Chihama K, Tomita K, Nakajima K, Nabeshima Y, Hoshino M:
  Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking.
  Neuron, 67, 588-602, 2010
• Nishida K, Hoshino M, Kawaguchi Y, Murakami F:
  Ptf1a directly controls expression of immunoglobulin superfamily molecules Nephrin and Neph3 in the developing central nervous system.
  J. Biol. Chem. 285, 373-380, 2010
• Nishimura YV, Sekine K, Chihama K, Nakajima K, *Hoshino M, Nabeshima Y, *Kawauchi T:
  Dissecting the factors involved in the locomotion mode of neuronal migration in the developing cerebral cortex.
  J. Biol. Chem. 285, 5878-5887, 2010
• Iritani S, Sekiguchi H, Habuchi C, Hikita T, Taya S, Kaibuchi K, Ozaki N:
  Immunohistochemical study of vesicle monoamine transporter 2 in the hippocampal region of genetic animal model of schizophrenia.
  Synapse, 64, 948-953, 2010
• Miyahara K, Kato Y, Koga H, Lane GJ, Inoue T, Akazawa C, Yamataka, A:
  Abnormal enteric innervation identified without histopathologic staining in aganglionic colorectum from a mouse model of Hirschsprung’s disease.
  J Pediatr Surg. 45:2403-2407, 2010.
• Shibata S, Yasuda A, Renault-Mihara F, Suyama S, Katoh H, Inoue T, Inoue YU, Nagoshi N, Sato M, Nakamura M, Akazawa C, Okano H:
  Sox10-Venus mice: a new tool for real-time labeling of neural crest lineage cells and oligodendrocytes.
  Mol. Brain 3:31, 2010

2009

• Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M:
  Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1.
  Development, 136, 2049-2058, 2009
• Causeret F, Terao M, Jacobs T, Nishimura YV, Yanagawa Y, Obata K, Hoshino M, Nikolic M:
  The p21-activated kinase is required for neuronal migration in the cerebral cortex.
  Cerebral Cortex, 19, 861-875, 2009
• Inoue YU, Asami J, Inoue T:
  Genetic labeling of mouse rhombomeres by Cadherin-6::EGFP-BAC transgenesis underscores the role of cadherins in hindbrain compartmentalization.
  Neurosci. Res., 63, 2-9, 2009
• Sone M, Uchida A, Komatsu A, Suzuki E, Ibuki I, Asada M, Shiwaku H, Tamura T, Hoshino M, OkazawaH, Nabeshima Y:
  Loss of yata, a novel gene regulating the subcellular localization of APPL, induces deterioration of neural tissues and lifespan shortening.
  PloS ONE, 4, e4466, 2009
• Qin J, Xie Y, Wang B, Hoshino M, Wolff DW, Zhao J, Scofield MA, Dowd FJ, Lin M-F, Tu Y:
  Upregulation of PIP3-dependent Rac exchanger 1 (P-Rex1) promotes prostate cancer metastasis.
  Oncogene, 28, 1853-1863, 2009
• Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP, Martemyanov KA:
  Retina specific GTPase accelerator RGS11/Gb5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons.
  J. Neurosci. 29, 9301-9313, 2009
• Ono K, Nakagawa T, Kojima K, Matsumoto M, Kawauchi T, Hoshino M, Ito J:
  Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae.
  Mol Cell Neurosci. 42, 391-398, 2009
• Enomoto A, Asai N, Namba T, Wang Y, Kato T, Tanaka M, Tatsumi H, Taya S, Tsuboi D, Kuroda K, Kaneko N, Sawamoto K, Miyamoto R, Jijiwa M, Murakumo Y, Sokabe M, Seki T, Kaibuchi K, Takahashi M:
  Roles of disrupted-in-schizophrenia 1-interacting protein girdin in postnatal development of the dentate gyrus.
  Neuron, 63, 774-787, 2009
• Hikita T, Taya S, Fujino Y, Taneichi-Kuroda S, Ohta K, Tsuboi D, Shinoda T, Kuroda K, Funahashi Y, Uraguchi-Asaki J, Hashimoto R, Kaibuchi K:
  Proteomic analysis reveals novel binding partners of dysbindin, a schizophrenia-related protein.
  J. Neurochem., 110, 1567-1574, 2009
• Hashimoto R, Ohi K, Okada T, Yasuda Y, Yamamori H, Hori H, Hikita T, Taya S, Saitoh O, Kosuga A, Tatsumi M, Kamijima K, Kaibuchi K, Takeda M, Kunugi H:
  Association analysis between schizophrenia and the AP-3 complex genes.
  Neurosci. Res., 65, 113-115, 2009
• Arimura N, Kimura T, Nakamuta S, Taya S, Funahashi Y, Hattori A, Shimada A, Ménager C, Kawabata S, Fujii K, Iwamatsu A, Segal RA, Fukuda M, Kaibuchi K:
  Anterograde transport of TrkB in axons is mediated by direct interaction with Slp1 and Rab27.
  Dev. Cell, 16, 675-686, 2009
• Taneichi-Kuroda S, Taya S, Hikita T, Fujino Y, Kaibuchi K:
  Direct interaction of Dysbindin with the AP-3 complex via its mu subunit.
  Neurochem. Int., 54, 431-438, 2009

2008

• Inoue T, Inoue YU, Asami J, Izumi H, Nakamura S, Krumlauf R:
  Analysis of mouse Cdh6 gene regulation by transgenesis of modified bacterial artificial chromosomes.
  Dev Biol, 315, 506-520, 2008
• Fukuda A, Kawaguchi Y, Furuyama F, Kodama S, Horiguchi M, Kuhara T, Kawaguchi M, Terao M, Doi R, Wright CVE, Hoshino M, Chiba T, Uemoto S:
  Reduction of Ptf1a gene dosage causes pancreatic hypoplasia and diabetes mellitus in mice.
  Diabetes, 57, 2421-2431, 2008
• Masuho I, Mototani Y, Sahara Y, Asami J, Nakamura S, Kozasa T, Inoue, T:
  Dynamic expression patterns of G protein-regulated inducer of neurite outgrowth 1 (GRIN1) and its colocalization with Gao implicate significant roles of Gao-GRIN1 signaling in nervous system.
  Dev. Dyn. 237, 2415-2429, 2008
• Inoue YU, Asami J, Inoue T:
  Cadherin-6 gene regulatory patterns in the postnatal mouse brain.
  Mol. Cell. Neurosci., 39, 95-104, 2008.
• Kumanogoh H, Asami J, Nakamura S, Inoue T:
  Balanced expression of various TrkB receptor isoforms from the Ntrk2 gene locus in the mouse nervous system.
  Mol Cell Neurosci. 39, 465-477, 2008
• Tsuda R, Kumanogoh H, Umeda M, Maekawa S:
  Morphological analysis on the distribution of membrane lipids and a membrane protein, NAP-22, during neuronal development in vitro.
  J Mol Histol. 39, 371-379. 2008
• Masutani T, Taguchi K, Kumanogoh H, Nakamura S, Maekawa S:
  Molecular interaction of neurocalcin alpha with alsin (ALS2).
  Neurosci. Lett. 438, 26-28, 2008
• Maimaitiyiming M, Kumanogoh H,Nakamura S, Nagata K, Suzaki T, Maekawa S:
  Biochemical characterization of membrane-associated septin from rat brain.
  J Neurochem. 106, 1175-1183, 2008

2007

• Yamada M, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y, Hoshino M:
  Origin of climbing fiber neurons and their developmental dependence on Ptf1a.
  (The same journal's Journal Club commented on this paper. J. Neurosci. 9, 338-339, 2008)
• Takemoto-Kimura S, Ishihara-Ageta N, Nonaka M, Adachi-Morishima A, Mano T, Okamura M, Fujii H, Fuse T, Hoshino M, Suzuki S, Kojima M, Mishina M, Okuno H, Bito H:
  Regulation of dendritogenesis via a lipid raft-associated Ca2+/calmodulin-dependent proteini kinase CLICK-III/CaMKIg.
  Neuron, 54, 755-770, 2007
• Shima Y, Kawaguchi SY, Kosaka K, Nakayama M, Hoshino M, Nabeshima Y, Hirano T, Uemura T:
  Opposing roles in neurite growth control by two 7-pass transmembrane cadherins.
  Nature Neuroscience, 10, 963-969, 2007
• Jacobs T, Causeret F, Nishimura YV, Terao M, Norman A, Hoshino M, Nikolic M:
  Localized activation of Pak1 controls neuronal polarity and morphology.
  J. Neurosci., 27, 8604-8615, 2007
  (Selected in “This week in the journal”)
• Causeret F, Jacobs T, Terao M, Heath O, Hoshino M, Nikolic M:
  Neurabin-I is phosphorylated by Cdk5: implications for neuronal morphogenesis and cortical migration.
  Molecular Biol. Cell, 18, 4327-4342, 2007
  (It was on the cover of a magazine)
• Zhao T, Nalbant P, Hoshino M, Dong X, Wu D, Bokoch GM:
  Signaling requirements for translocation of P-Rex1, a key Rac2 exchange factor involved in chemoattractant-stimulated human neutrophil function.
  J. Leukocyte Biol., 81, 1127-1136, 2007
• Takefuji M, Mori K, Morita Y, Arimura N, Nishimura T, Nakayama M, Hoshino M, Iwamatsu A, Murohara T, Kaibuchi K, Amano M:
  Rho-kinase modulates the function of STEF, a Rac GEF, through its phosphorylation.
  Biochem. Biophys. Res. Comm., 355, 788-794, 2007
• ZalduaN , Gastineau M, Hoshino M, Lezoualc’h F, Zugaza JL:
  Epac signaling pathway involves STEF a guanine nucleotide exchange factor for Rac to regulate APP processing.
  FEBS Letter 581, 5814-5818, 2007

2006

• Kawauchi T, Chihama K, Nabeshima Y, Hoshino M:
  Cdk5 phosphorylates and stabilizes p27kip1, contributing to actin organization and cortical neuronal migration.
  Nature Cell Biol. 8, 17-26, 2006
  (Featured in News & Views in the same issue)

2005

• Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y:
  Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum.
  Neuron, 47, 201-213, 2005
• Yoshizawa M, Kawauchi T, Sone M, Nishimura YV, Terao M, Chihama K, Nabeshima Y, Hoshino M:
  Involvement of a Rac activator, P-Rex1, in neurotrophin-derived signaling and neuronal migration.
  J. Neurosci. 25, 4406-4419, 2005
• Kawauchi T, Chihama K, Nishimura YV, Nabeshima Y, Hoshino M:
  MAP1B phosphorylation is differentially regulated by Cdk5/p35, Cdk5/p25 and JNK.
  Biochem. Biophys. Res. Comm., 331, 50-55, 2005
• Dezawa M, Ishikawa H, Itokazu Y, Yoshihara T, Hoshino M, Takeda S, Ide C, Nabeshima Y:
  Bone marrow stromal cells generate muscle cells and repair muscle degeneration.
  Science, 309, 314-317 (2005)
• Nishimura T, Yamaguchi T, Kato K, Yoshizawa M, Nabeshima Y, Ohno S, Hoshino M, Kaibuch K:
  PAR-6-PAR-3 mediates Cdc42 signaling to Rac activation through STEF/Tiam1, RacGEFs.
  Nature Cell Biol. 7, 270-277, 2005

2004

• Dezawa M, Kanno H, Hoshino M, Cho H, Matsumoto N, Itokazu Y, Tajima N, Yamada H, Sawada H, Ishikawa H, Mimura T, Kitada M, Suzuki Y, Ide C:
  Specific induction of neuronal cells from bone-marrow stromal cells and application for autologous transplantation.
  J. Clin. Invest., 113, 1701-1710, 2004

2003

• Kawauchi T, Chihama K, Nabeshima Y, Hoshino M:
  The in vivo roles of STEF/Tiam1, Rac1 and JNK in cortical neuronal migration.
  EMBO Journal, 22, 4190-4201, 2003
• Yoshizawa M, Sone M, Matsuo N, Nagase T, Ohara O, Nabeshima Y, Hoshino M:
  Dynamic and coordinated expression profiles of Dbl-family guanine nucleotide exchange factors in the developing mouse brain.
  Gene Expression Patterns, 3, 375-381, 2003
• Matsuo N, Terao M, Nabeshima Y, Hoshino M:
  Roles of STEF/Tiam1, guanine necleotide exchange factors for Rac1, in regulation of growth cone morphology.
  Mol. Cell. Neurosci., 24, 69-81, 2003
  (It was on the cover of a magazine)

2002

• Yoshizawa M, *Hoshino M, Sone M, Nabeshima Y:
  Expression of stef, an activator of Rac1, correlates with the stages of neuronal morphological development in the mouse brain.
  Mech. Dev., 113, 65-68, 2002 (*corresponding author)
• Matsuo M, *Hoshino M, Yoshizawa Y, Nabeshima Y:
  Characterization of STEF, a guanine nucleotide exchange factor for Rac1, required for neurite growth.
  J. Biol. Chem. 277, 2860-2868, 2002 (*corresponding author)

- 2000

• Sone M, Suzuki E, Hoshino M, Hou D, Kuromi H, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C:
  Synaptic development is controlled in the periactive zones of Drosophila synapses.
  Development,127, 4157-4168, 2000
• Hoshino M, Sone M, Fukata M, Kuroda S, Kaibuchi K, Nabeshima Y, Hama C:
  Identification of the stef gene that encodes a novel guanine-nucleotide exchange factor specific for Rac1.
  J. Biol. Chem., 274, 17837-17844, 1999
• Hoshino M, Suzuki E, Miyake T, Sone M, Komatsu A, Nabeshima Y, Hama C:
  Neural expression of Hikaru genki protein during embryonic and larval development of Drosophila melanogaster
  Dev. Genes Evol.,209, 1-9, 1999
• Sone M, Hoshino M, Suzuki E, Kuroda S, Kaibuchi K, Nakagoshi H, Saigo K, Nabeshima Y, Hama C:
  Still life, a protein in synaptic terminals of Drosophila homologous to GDP-GTP exchangers.
  Science, 275, 543-547, 1997
• Hoshino M, Suzuki E, Nabeshima Y, Hama C:
  Hikaru genki protein is secreted into synaptic clefts from an early stage of synapse formation in Drosophila
  Development, 122, 589-597, 1996
• Hoshino M, Matsuzaki F, Nabeshima Y, Hama C:
  hikaru genki, a CNS-specific gene identified by abnormal locomotion in Drosophila, encodes a novel type of protein.
  Neuron, 10, 395-407, 1993

Review Articles & Books

English

• Hori K, Shimaoka K, Hoshino M.
  AUTS2 Gene: Keys to understanding the pathogenesis of neurodevelopmental disorders.
  Cells. 2021 Dec 21; 11(1). doi: 10.3390/cells11010011.
• Hori K,Hoshino M:
  Neuronal Migration and AUTS2 Syndrome.
  Brain Sci. 2017 May 14;7(5):54. doi: 10.3390/brainsci70500542
• Hori K,Hoshino M:
  GABAergic neuron specification in the spinal cord, the cerebellum and the cochlear nucleus
  Neural Plasticity, 2012:921732, 2012
• Hoshino M:
  Neuronal subtype specification in the cerebellum and dorsal hindbrain.
  Dev Growth Differ, 54, 317-326, 2012
• Hoshino M, Seto Y, Yamada M:
  Specification of cerebellar and precerebellar neurons: HANDBOOK OF THE CEREBELLUM AND CEREBELLAR DISORDERS, Springer, 2012
• Kawauchi T, Hoshino M:
  Molecular pathways regulating cytoskeletal organization and morphological changes in migrating neurons
  Developmental Neuroscience, 30, 36-46, 2008
• Hoshino M:
  Molecular machinery governing GABAergic neuron specification in the cerebellum.
  The Cerebellum, 5, 193-198, 2006
• Dezawa M, Hoshino M, Ide C:
  Treatment of neurodegenerative diseases using adult bone marrow stromal cell-derived neurons.
  Expert Opinion on Biological Therapy, 5, 427-435, 2005
• Dezawa M, Hoshino M, Nabeshima Y, Ide C:
  Marrow stromal cells: implications in health and disease in the nervous system.
  Current Molecular Medicine, 5, 653-662, 2005
• Dezawa M, Ishikawa H, Hoshino M, Itokazu Y, Nabeshima Y:
  Potential of bone marrow stromal cell in application to neurodegenerative and muscle degenerative diseases.
  Current Neuropharmacology 3, 257-266, 2005