National Center ofNeurology and Psychiatry

Department ofBiochemistry & Cellular Biology

Science TokyoNCNP Brain Physiology and Pathology,Science Tokyo

Cerebellar Development Research Group

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What's news

  • 2024.09.27
  • Research Fellow Dr. Toru Adachi has been selected as a 2025 Japan Society for the Promotion of Science (JSPS) Postdoctoral Fellow.
  • 2024.07.25
  • Doctoral student Kyoka Suyama gave a poster presentation at Neuro2024 titled "A detailed exploration of the progeny cell types produced by cerebellar Bergmann glia like progenitor" and master's student Minami Mizuno gave a poster presentation titled "Exploring the function of transcription factor MEIS1 in cerebellar glial cell development."

Research Summary

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1. Function of transcription factor MEIS1 in cerebellar development

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2.Elucidation of the mechanism controlling the timing of proliferation and differentiation in cerebellar granule cell precursors

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Publications

  • Owa T, Shiraishi R, Adachi A, Miyashita S, Ichijo K, Nishioka T, Taya S, Kaibuchi K, Hoshino M. Homeodomain-less MEIS1 suppresses CUL3-dependent ATOH1 degradation to regulate cerebellar granule cell development. Biorxiv 2022. doi:10.1101/2022.08.17.504235
  • Miyashita S, Hoshino M. Transit amplifying progenitors in the cerebellum: Similarities to and differences from transit amplifying cells in other brain regions and between species. Cells. 2022 Feb 18;11(4): 726. doi: 10.3390/cells11040726.
  • Miyashita S, Owa T, Seto Y, Yamashita M, Aida S, Sone M, Ichijo K, Nishioka T, Kaibuchi K, Kawaguchi Y, Taya S, Hoshino M. Cyclin D1 controls development of cerebellar granule cell progenitors through phosphorylation and stabilization of ATOH1. EMBOJ 2021 Jul 15; 40(14): e105712. doi: 10.15252/emboj.2020105712.
  • Adachi T, Miyashita S, Yamashita M, Shimoda M, Okonechnikov K, Chavez L, Kool M, Pfister SM, Inoue T, Kawauchi D, Hoshino M. Notch Signaling between Cerebellar Granule Cell Progenitors. eNeuro. 2021:ENEURO.0468-20.
  • Yamashita M, Owa T, Shiraishi R, Adachi T, Ichijo K, Taya S, Miyashita S, Hoshino M. The role of SCFSkp2 and SCFβ-TrCP1/2 in the cerebellar granule cell precursors. Genes to Cells. 2020 Oct 6. doi: 10.1111/gtc.12813.
  • Shiraishi RD, Miyashita S, Yamashita M, Adachi T, Shimoda MM, Owa T, Hoshino M. Expression of transcription factors and signaling molecules in the cerebellar granule cell development. Gene Expr Patterns. 2019 Dec;34:119068. doi: 10.1016/j.gep.2019.119068. Epub 2019 Aug 20.PMID: 31437514
  • Fujiyama T, Miyashita S, Tsuneoka Y, Kanemaru K, Kakizaki M, Kanno S, Ishikawa Y, Yamashita M, Owa T, Nagaoka M, Kawaguchi Y, Yanagawa Y, Magnuson MA, Marutani M, Shibuya A, Nabeshima Y, Yanagisawa M, Funato H and Hoshino M. Forebrain Ptf1a is required for sexual differentiation of the brain. Cell Rep., 2018 July 3; 24(1):79-94. doi:10.1016/j.celrep.2018.06.010
  • Owa T, Taya S, Miyashita S, Yamashita M, Adachi T, Yamada K, Yokoyama M, Aida S, Nishioka T, Inoue YU, Goitsuka R, Nakamura T, Inoue T, Kaibuchi K, Hoshino M: Meis1 Coordinates Cerebellar Granule Cell Development by Regulating Pax6 Transcription, BMP Signaling and Atoh1 Degradation. J Neurosci, 2018 Jan 31;38(5):1277-1294. doi: 10.1523/JNEUROSCI.1545-17.2017. Epub 2018 Jan 9.
  • Miyashita S*, Adachi T*, Yamashita M, Sota T, Hoshino M: Dynamics of the cell division orientation of granule cell precursors during cerebellar development. Mech Dev, 2017 Oct;147:1-7. doi: 10.1016/j.mod.2017.06.002. Epub 2017 Jun 17. *These authors contributed equally.
  • Hashimoto R, Hori K, Owa T, Miyashita S, Dewa K, Masuyama N, Sakai K, Hayase Y, Seto Y, Inoue YU, Inoue T, Ichinohe N, Kawaguchi Y, Akiyama H, Koizumi S, Hoshino M:Origins of oligodendrocytes in the cerebellum, whose development is controlled by the transcription factor, Sox9. Mech Dev, May;140:25-40. doi: 10.1016/j.mod.2016.02.004. Epub 2016 Mar 3.
  • Leto K, Arancillo M, Becker EB, Buffo A, Chiang C, Ding B, Dobyns WB, Dusart I, Haldipur P, Hatten ME, Hoshino M, Joyner AL, Kano M, Kilpatrick DL, Koibuchi N, Marino S, Martinez S, Millen KJ, Millner TO, Miyata T, Parmigiani E, Schilling K, Sekerková G, Sillitoe RV, Sotelo C, Uesaka N, Wefers A, Wingate RJ, Hawke: Consensus paper: cerebellar development. Cerebellum, 2016 Dec;15(6):789-828. Review.
  • De Luca A, Parmigiani E, Tosatto G, Martire S, Hoshino M, Buffo A, Leto K, Rossi F: Exogenous Sonic Hedgehog modulates the pool of GABAergic interneurons during cerebellar development. Cerebellum, 14, 72-85, 2015.
  • Seto Y, Nakatani T, Masuyama N, Taya S, Kumai M, Minaki Y, Hamaguchi A, Inoue YU, Inoue T, Miyashita S, Fujiyama T, Yamada M, Chapman H, Campbell KJ, Magnuson MA, Wright CV, Kawaguchi Y, Ikenaka K, Takebayashi H, Ishiwata S, Ono Y, Hoshino M: Temporal identity transition from Purkinje cell progenitors to GABAergic interneuron progenitors in the cerebellum. Nature Communications, 5, 3337, 2014.
  • Yamada M, Seto Y, Taya S, Owa T, Inoue YU, Inoue T, Kawaguchi Y, Nabeshima Y, Hoshino M. Specification of spatial identities of cerebellar neuronal progenitors by Ptf1a and Atoh1 for proper production of GABAergic and glutamatergic neurons. J. Neurosci, 34, 4786-4800, 2014.
  • Seto Y, Ishiwata S, Hoshino M: Characterization of Olig2 expression during cerebellar development. Gene Expression Patterns, 15, 1-7, 2014.
  • Kawauchi T, Sekine K, Shikanai M, Chihama K, Tomita K, Nakajima K, Nabeshima Y, Hoshino M: Rab GTPases-dependent endocytic pathways regulate neuronal migration and maturation through N-Cadherin trafficking. Neuron, 67, 588-602, 2010.
  • Fujiyama T, Yamada M, Terao M, Terashima T, Hioki H, Inoue YU, Inoue T, Masuyama N, Obata K, Yanagawa Y, Kawaguchi Y, Nabeshima Y, Hoshino M: Inhibitory and excitatory subtypes of cochlear nucleus neurons are defined by distinct bHLH transcription factors, Ptf1a and Atoh1. Development, 136, 2049-2058, 2009.
  • Yamada M, Terao M, Terashima T, Fujiyama T, Kawaguchi Y, Nabeshima Y, Hoshino M: Origin of climbing fiber neurons and their developmental dependence on Ptf1a. J. Neurosci., 27, 10924-10934, 2007)
  • Kawauchi T, Chihama K, Nabeshima Y, Hoshino M: Cdk5 phosphorylates and stabilizes p27kip1, contributing to actin organization and cortical neuronal migration. Nature Cell Biol. 8, 17-26, 2006
  • Hoshino M, Nakamura S, Mori K, Kawauchi T, Terao M, Nishimura YV, Fukuda A, Fuse T, Matsuo N, Sone M, Watanabe M, Bito H, Terashima T, Wright CVE, Kawaguchi Y, Nakao K, Nabeshima Y: Ptf1a, a bHLH transcriptional gene, defines GABAergic neuronal fates in cerebellum. Neuron, 47, 201-213, 2005
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